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1. (WO2018196805) POLYMORPH OF COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
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Pub. No.: WO/2018/196805 International Application No.: PCT/CN2018/084608
Publication Date: 01.11.2018 International Filing Date: 26.04.2018
IPC:
C07D 487/04 (2006.01) ,A61P 31/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
Applicants:
齐鲁制药有限公司 QILU PHARMACEUTICAL CO., LTD. [CN/CN]; 中国山东省济南市 高新区新泺大街317号 No. 317, Xinluo Street, High Technical Zone Jinan, Shandong 250100, CN
Inventors:
申建伟 SHEN, Jianwei; CN
张进 ZHANG, Jin; CN
李龙 LI, Long; CN
高永宏 GAO, Yonghong; CN
张占涛 ZHANG, Zhantao; CN
张勇 ZHANG, Yong; CN
Agent:
北京知元同创知识产权代理事务所(普通合伙) BEIJING ORIGINTELLIGENCE IP LAW FIRM; 中国北京市 海淀区上地三街9号嘉华大厦E座1004室刘元霞 LIU, Yuanxia Room 1004, Tower E, Jiahua Building No. 9, Shangdi 3rd Street, Haidian District Beijing 100085, CN
Priority Data:
201710295287.928.04.2017CN
Title (EN) POLYMORPH OF COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) POLYMORPHE DE COMPOSÉ, PROCÉDÉ DE PRÉPARATION S'Y RAPPORTANT ET UTILISATION DE CELUI-CI
(ZH) 化合物的多晶型、其制备方法和用途
Abstract:
(EN) The present invention relates to a polymorph of a compound (3R,6S)-6-aminosulfonylamino-1-(thiazol-2-yl)-3-(2,3,4-trifluorophenyl)-3,5,6,7-tetrahydropyrrolo[1,2-c]pyrimidin-4-methyl formate (compound 1). The present invention further relates to a pharmaceutical composition and pharmaceutical use of the polymorph of compound 1, and a preparation method for the polymorph of compound 1.
(FR) La présente invention concerne un polymorphe d'un composé formiate de (3R,6S)-6-aminosulfonylamino-1-(thiazol-2-yl)-3-(2,3,4-trifluorophényl) 3,5,6,7-tétrahydropyrrolo[1,2-c]pyrimidin-4-ylméthyle (composé 1). La présente invention concerne en outre une composition pharmaceutique et une utilisation pharmaceutique du polymorphe du composé 1 et un procédé de préparation pour le polymorphe du composé 1.
(ZH) 本发明涉及化合物(3R,6S)-6-氨磺酰基氨基-1-(噻唑-2-基)-3-(2,3,4-三氟苯基)-3,5,6,7-四氢吡咯并[1,2-c]嘧啶-4-甲酸甲酯(化合物1)的多晶型物。本发明还涉及化合物1多晶型物的药用组合物、制药用途及化合物1多晶型物的制备方法。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)