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1. (WO2018196768) HETEROCYCLIC COMPOUND SERVING AS PD-L1 INHIBITOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/196768 International Application No.: PCT/CN2018/084352
Publication Date: 01.11.2018 International Filing Date: 25.04.2018
IPC:
C07D 271/06 (2006.01) ,C07D 285/08 (2006.01) ,A61K 31/4245 (2006.01) ,A61K 31/433 (2006.01) ,A61P 31/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
271
Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02
not condensed with other rings
06
1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
285
Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01
Five-membered rings
02
Thiadiazoles; Hydrogenated thiadiazoles
04
not condensed with other rings
08
1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
433
Thiadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Applicants:
南京圣和药业股份有限公司 NANJING SANHOME PHARMACEUTICAL CO., LTD. [CN/CN]; 中国江苏省南京市 栖霞区经济技术开发区惠中路9号 9 Huizhong Road, Nanjing Economic and Technological Development Zone, Qixia Nanjing, Jiangsu 210038, CN
Inventors:
王勇 WANG, Yong; CN
赵立文 ZHAO, Liwen; CN
刘欣 LIU, Xin; CN
尹伟 YIN, Wei; CN
刘笑 LIU, Xiao; CN
于琪 YU, Qi; CN
Agent:
南京天华专利代理有限责任公司 NANJING TIANHUA PATENT AGENT CO., LTD.; 中国江苏省南京市 鼓楼区山西路67号世贸中心大厦A1座23层 Floor 23, Block A1, World Trade Center Building No. 67 Shanxi Road, Gulou Nanjing, Jiangsu 210009, CN
Priority Data:
201710280707.626.04.2017CN
Title (EN) HETEROCYCLIC COMPOUND SERVING AS PD-L1 INHIBITOR
(FR) COMPOSÉ HÉTÉROCYCLIQUE SERVANT D'INHIBITEUR DE PD-L1
(ZH) 作为PD-L1抑制剂的杂环类化合物
Abstract:
(EN) The present invention relates to the field of medical chemistry, and relates to a heterocyclic compound serving as a PD-L1 inhibitor. Specifically, the present invention relates to a compound represented by formula A, or an isomer, pharmaceutically acceptable salt, solvate or prodrug thereof, preparation methods therefor, a pharmaceutical composition containing these compounds, and a use of these compounds or composition in treating cancers or infectious diseases.
(FR) La présente invention se rapporte au domaine de la chimie médicale, et concerne un composé hétérocyclique faisant office d'inhibiteur de PD-L1. La présente invention concerne particulièrement un composé représenté par la formule A, ou un isomère, un sel pharmaceutiquement acceptable, un solvate ou un promédicament de celui-ci, des procédés de préparation correspondants, une composition pharmaceutique contenant ces composés, et une utilisation de ces composés ou composition dans le traitement de cancers ou de maladies infectieuses.
(ZH) 本发明属于医药化学领域,涉及一类作为PD-L1抑制剂的杂环类化合物及其应用,具体地,本发明涉及式A所示的化合物或其异构体、药学上可接受的盐、溶剂化物或前药,它们的制备方法以及含有这些化合物的药物组合物和这些化合物或组合物用于治疗癌症或者感染类疾病的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)