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|1. (WO2018196681) EUTECTIC OF NIFEDIPINE WITH ISONICOTINAMIDE|
|Applicants:||SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
|Title:||EUTECTIC OF NIFEDIPINE WITH ISONICOTINAMIDE|
Disclosed is a eutectic of nifedipine with isonicotinamide, and a preparation method and uses thereof. The eutectic of nifedipine with isonicotinamide is fully characterized by means of X-ray single crystal diffraction analysis, X-ray powder diffraction analysis, thermogravimetric analysis, differential scanning calorimetry and infrared spectroscopy, etc.; the eutectic is found to have the advantage of higher light stability compared to the nifedipine. The preparation method of the eutectic of nifedipine and isonicotinamide is simple, easy to control and has good reproducibility, and a stable eutectic of nifedipine and isonicotinamide can be obtained thereby.