Search International and National Patent Collections

1. (WO2018196681) EUTECTIC OF NIFEDIPINE WITH ISONICOTINAMIDE

Pub. No.:    WO/2018/196681    International Application No.:    PCT/CN2018/083815
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 21 01:59:59 CEST 2018
IPC: C07D 211/90
C07D 213/81
A61K 31/4422
A61K 47/22
A61P 9/00
A61P 9/12
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
中国科学院上海药物研究所
Inventors: MEI, Xuefeng
梅雪锋
YU, Qihui
余琦慧
WANG, Jianrong
王建荣
Title: EUTECTIC OF NIFEDIPINE WITH ISONICOTINAMIDE
Abstract:
Disclosed is a eutectic of nifedipine with isonicotinamide, and a preparation method and uses thereof. The eutectic of nifedipine with isonicotinamide is fully characterized by means of X-ray single crystal diffraction analysis, X-ray powder diffraction analysis, thermogravimetric analysis, differential scanning calorimetry and infrared spectroscopy, etc.; the eutectic is found to have the advantage of higher light stability compared to the nifedipine. The preparation method of the eutectic of nifedipine and isonicotinamide is simple, easy to control and has good reproducibility, and a stable eutectic of nifedipine and isonicotinamide can be obtained thereby.