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1. (WO2018196677) FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF
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Pub. No.: WO/2018/196677 International Application No.: PCT/CN2018/083792
Publication Date: 01.11.2018 International Filing Date: 19.04.2018
IPC:
C07C 233/11 (2006.01) ,C07C 311/16 (2006.01) ,A61K 31/18 (2006.01) ,A61K 31/166 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
02
having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
11
with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15
Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
16
having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
18
Sulfonamides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
166
having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
四川科伦博泰生物医药股份有限公司 SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. [CN/CN]; 中国四川省成都市 温江区海峡两岸科技产业开发园区新华大道二段666号 No. 666, Xinhua Avenue (Section 2), Hai Xia Industrial Park, Wenjiang District Chengdu, Sichuan 611138, CN
Inventors:
朱加望 ZHU, Jiawang; CN
宋智泉 SONG, Zhiquan; CN
杨龙 YANG, Long; CN
李睿 LI, Rui; CN
张帅 ZHANG, Shuai; CN
周林 ZHOU, Lin; CN
赵明亮 ZHAO, Mingliang; CN
唐祖建 TANG, Zujian; CN
钟维 ZHONG, Wei; CN
曾宏 ZENG, Hong; CN
宋宏梅 SONG, Hongmei; CN
周信 ZHOU, Xin; CN
谭玉婷 TAN, Yuting; CN
胡晓 HU, Xiao; CN
王利春 WANG, Lichun; CN
王晶翼 WANG, Jingyi; CN
Agent:
中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE; 中国北京市 西城区阜成门外大街2号万通新世界广场8层 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street, Xicheng District Beijing 100037, CN
Priority Data:
201710294651.X28.04.2017CN
Title (EN) FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF
(FR) DÉRIVÉ DE FLUOROALLYLAMINE ET SON UTILISATION
(ZH) 氟代烯丙胺衍生物及其用途
Abstract:
(EN) The present invention relates to a fluoroallylamine derivative and the use thereof. In particular, the present invention relates to a compound as shown in formula I, a prodrug, an isomer, an isotopically labelled compound, a solvate or a pharmaceutically acceptable salt thereof. The fluoroallylamine derivative has a VAP-1/SSAO inhibitory activity, and can be used for treating diseases associated with VAP-1/SSAO overactivity.
(FR) La présente invention concerne un dérivé de fluoroallylamine et son utilisation. En particulier, la présente invention concerne un composé tel que représenté par la formule I, un promédicament, un isomère, un composé marqué par un isotope, un solvate ou un sel pharmaceutiquement acceptable de celui-ci. Le dérivé de fluoroallylamine présente une activité inhibitrice de VAP-1/SSAO, et peut être utilisé pour traiter des maladies associées à une suractivité de VAP-1/SSAO.
(ZH) 本发明涉及氟代烯丙胺衍生物及其用途,具体的,本发明涉及式I所示化合物、其前药、异构体、同位素标记的化合物、溶剂化物或药学上可接受的盐,其具有VAP-1/SSAO抑制活性,可用于与VAP-1/SSAO过度活性相关的疾病的治疗。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)