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1. (WO2018196566) USE OF VCAM-1+ MONOCYTE AND DERIVED CELL THEREOF IN PROMOTING HEMATOPOIETIC STEM CELLS HOMING
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Pub. No.: WO/2018/196566 International Application No.: PCT/CN2018/081682
Publication Date: 01.11.2018 International Filing Date: 03.04.2018
IPC:
C12N 5/00 (2006.01) ,C12N 5/0786 (2010.01) ,C12N 5/071 (2010.01) ,A61K 35/14 (2015.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0786
Monocytes; Macrophages
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
中国科学院上海生命科学研究院 SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国上海市 徐汇区岳阳路319号 319 Yueyang Road, Xuhui District Shanghai 200031, CN
Inventors:
潘巍峻 PAN, Weijun; CN
李丹彤 LI, Dantong; CN
薛文志 XUE, Wenzhi; CN
李美 LI, Mei; CN
Agent:
上海一平知识产权代理有限公司 XU AND PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1 Universal High-Tech Plaza 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201710271668.324.04.2017CN
Title (EN) USE OF VCAM-1+ MONOCYTE AND DERIVED CELL THEREOF IN PROMOTING HEMATOPOIETIC STEM CELLS HOMING
(FR) UTILISATION D'UN MONOCYTE VCAM-1+ ET D'UNE CELLULE DÉRIVÉE DE CELUI-CI DANS L'ACTIVATION DE L'HÉBERGEMENT DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES
(ZH) VCAM-1+单核细胞及其衍生细胞在促进造血干细胞归巢的应用
Abstract:
(EN) Provided in the present invention is the use of VCAM-1+ monocytes and derived cells thereof in promoting hematopoietic stem cells homing. In particular, provided in the present invention is a composition or a preparation promoting hematopoietic stem cells homing. Also provided in the present invention is a method for determining a potential therapeutic agent promoting hematopoietic stem cells homing.
(FR) La présente invention concerne l'utilisation de monocytes VCAM-1+ et de cellules dérivées de ceux-ci dans l'activation de l'hébergement de cellules souches hématopoïétiques. La présente invention concerne en particulier une composition ou une préparation activant l'hébergement de cellules souches hématopoïétiques. La présente invention concerne également un procédé de détermination d'un agent thérapeutique potentiel activant l'hébergement de cellules souches hématopoïétiques.
(ZH) 本发明提供了VCAM-1 +单核细胞及其衍生细胞在促进造血干细胞归巢的应用,具体地,本发明提供了促进造血干细胞归巢的组合物或制剂,本发明还提供了确定促进造血干细胞归巢的潜在治疗剂的方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)