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1. (WO2018195956) METHOD FOR PREPARING SINGLE CRYSTAL OF ANHYDROUS HALOGENATED CHOLINE OR DERIVATIVE THEREOF

Pub. No.:    WO/2018/195956    International Application No.:    PCT/CN2017/082502
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 29 01:59:59 CEST 2017
IPC: C07C 215/40
C07C 213/10
Applicants: HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
河北科技大学
Inventors: DUAN, Erhong
段二红
LIAN, Shaohan
连少翰
CHEN, Zidan
陈子丹
REN, Hongwei
任红威
SUN, Hua
孙华
NIU, Jianrui
牛建瑞
Title: METHOD FOR PREPARING SINGLE CRYSTAL OF ANHYDROUS HALOGENATED CHOLINE OR DERIVATIVE THEREOF
Abstract:
Provided is a method for preparing a single crystal of an anhydrous halogenated choline or a derivative thereof, comprising the steps of: (1) proportionally weighing the halogenated choline or a derivative thereof, an alcohol or ether compound or a mixture of an alcohol or ether compound and a polyol; (2) placing the alcohol or ether compound or the mixture of the alcohol or ether compound and the polyol in a reactor, heating to 70-90 DEG C, adding the halogenated choline or derivative thereof and reacting thermostatically until a uniform and transparent eutectic solvent is formed; (3) colling programmedly the eutectic solvent to 15 DEG C and keeping at 15 DEG C to age C for a certain time until no further single crystal is precipitated; (4) filtering, washing and drying under reduced vacuum to obtain the single crystals of the anhydrous halogenated choline or the derivative thereof. The product has good light and heat stability, high moisture, deliquescence or caking resistance, is easily operable, and has non-volatile, less polluting and recycled solvents.