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1. WO2018195184 - METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS

Publication Number WO/2018/195184
Publication Date 25.10.2018
International Application No. PCT/US2018/028148
International Filing Date 18.04.2018
IPC
A61K 31/454 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • AEVI GENOMICS MEDICINE, INC. [US]/[US]
  • THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US]/[US]
Inventors
  • NEIL, Garry A.
  • SQUIRES, Liza
  • HAKONARSON, Hakon
Agents
  • BAUR, Amelia Feulner
  • MCNEILL, Rebecca M.
  • SCARR, Rebecca B.
  • DOHERTY, Elizabeth A.
  • HENNINGER, Mary R.
  • LEE, Victoria S.
Priority Data
62/487,43919.04.2017US
62/487,44519.04.2017US
62/544,44111.08.2017US
62/544,44711.08.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
(FR) PROCÉDÉS DE DIAGNOSTIC ET DE TRAITEMENT DU TDAH CHEZ DES SUJETS POSITIFS À DES BIOMARQUEURS
Abstract
(EN)
This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
(FR)
La présente invention concerne l'identification d'un sous-ensemble de variations du nombre de copies de gènes du réseau de mGluR qui prédisent l'efficacité du traitement par fasoracétam, ainsi que l'identification d'une variation du nombre de copies de gènes du réseau de mGluR qui prédit une probabilité accrue d'être atteint de TDAH ainsi que de présenter certains symptômes associés au TDAH.
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