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1. (WO2018195184) METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2018/195184 International Application No.: PCT/US2018/028148
Publication Date: 25.10.2018 International Filing Date: 18.04.2018
IPC:
A61K 31/454 (2006.01) ,A61K 45/06 (2006.01) ,A61P 25/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
454
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
AEVI GENOMICS MEDICINE, INC. [US/US]; 435 Devon Park Drive Suite 715 Wayne, Pennsylvania 19087, US
THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US/US]; 3401 Civic Center Boulevard Philadelphia, Pennsylvania 19104, US
Inventors:
NEIL, Garry A.; US
SQUIRES, Liza; US
HAKONARSON, Hakon; US
Agent:
BAUR, Amelia Feulner; US
MCNEILL, Rebecca M.; US
SCARR, Rebecca B.; US
DOHERTY, Elizabeth A.; US
HENNINGER, Mary R.; US
LEE, Victoria S.; US
Priority Data:
62/487,43919.04.2017US
62/487,44519.04.2017US
62/544,44111.08.2017US
62/544,44711.08.2017US
Title (EN) METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
(FR) PROCÉDÉS DE DIAGNOSTIC ET DE TRAITEMENT DU TDAH CHEZ DES SUJETS POSITIFS À DES BIOMARQUEURS
Abstract:
(EN) This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
(FR) La présente invention concerne l'identification d'un sous-ensemble de variations du nombre de copies de gènes du réseau de mGluR qui prédisent l'efficacité du traitement par fasoracétam, ainsi que l'identification d'une variation du nombre de copies de gènes du réseau de mGluR qui prédit une probabilité accrue d'être atteint de TDAH ainsi que de présenter certains symptômes associés au TDAH.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)