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1. WO2018193414 - PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES

Publication Number WO/2018/193414
Publication Date 25.10.2018
International Application No. PCT/IB2018/052753
International Filing Date 20.04.2018
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA [PT]/[PT]
Inventors
  • DA COSTA PEREIRA ROSA, Carla Patrícia
  • RAMOS DAMIL, João Carlos
  • CORDEIRO SIMÕES, Ana Vanessa
  • SILVA SERRA, João Pedro
Agents
  • TEIXEIRA DE CARVALHO, Anabela
Priority Data
11003721.04.2017PT
17167851.924.04.2017EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES
(FR) PROCÉDÉ DE PRÉPARATION D'UN CYCLE PIPÉRAZINE POUR LA SYNTHÈSE DE DÉRIVÉS DE PYRAZINOCARBAZOLE
Abstract
(EN) The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salt thereof.
(FR) La présente invention concerne un procédé amélioré pour la synthèse d'un cycle pipérazine, en particulier pour la préparation de composés hétérocycliques utiles en tant qu'intermédiaires dans la synthèse de pyrazinocarbazoles tels que le pirlindole antidépresseur. Le procédé de l'invention est utile pour préparer des énantiomères de pirlindole, ou un sel pharmaceutiquement acceptable de ceux-ci.
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