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1. WO2018189554 - SMALL MOLECULES

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Publication Number WO/2018/189554
Publication Date 18.10.2018
International Application No. PCT/GB2018/050987
International Filing Date 13.04.2018
IPC
C07D 417/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
C07K 5/062 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
062the side chain of the first amino acid being acyclic, e.g. Gly, Ala
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 38/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
C07K 5/06034
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
06034the side chain containing 2 to 4 carbon atoms
C07K 5/06165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
06165and Pro-amino acid; Derivatives thereof
C07K 5/06191
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06191containing heteroatoms different from O, S, or N
Applicants
  • UNIVERSITY OF DUNDEE [GB]/[GB]
Inventors
  • CIULLI, Alessio
  • MANIACI, Chiara
  • HUGHES, Scott J.
  • TESTA, Andrea
Agents
  • HGF LIMITED
Priority Data
1706042.714.04.2017GB
1706043.514.04.2017GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SMALL MOLECULES
(FR) PETITES MOLÉCULES
front page image
Abstract
(EN) Compounds having the general structure A - L - B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1 B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.
(FR) L'invention concerne des composés ayant la structure générale A - L - B dans laquelle A et B sont indépendamment un composé ligand de liaison protéique d'ubiquitine ligase E3 de formule 1A ou 1B. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et des procédés d'utilisation.
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