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1. (WO2018186267) HYDROPHILIC COLORING CELLULOSE MICROPARTICLES
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2018/186267 International Application No.: PCT/JP2018/012938
Publication Date: 11.10.2018 International Filing Date: 28.03.2018
IPC:
G01N 33/543 (2006.01) ,G01N 33/548 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
544
the carrier being organic
548
Carbohydrates, e.g. dextran
Applicants:
旭化成株式会社 ASAHI KASEI KABUSHIKI KAISHA [JP/JP]; 東京都千代田区有楽町一丁目1番2号 1-1-2 Yurakucho, Chiyoda-ku, Tokyo 1000006, JP
Inventors:
塩見 祥之 SHIOMI, Yoshiyuki; JP
堀井 厚志 HORII, Atsushi; JP
松瀬 武志 MATSUSE, Takeshi; JP
村岡 謙 MURAOKA, Ken; JP
Agent:
青木 篤 AOKI, Atsushi; JP
三橋 真二 MITSUHASHI, Shinji; JP
中村 和広 NAKAMURA, Kazuhiro; JP
齋藤 都子 SAITO, Miyako; JP
三間 俊介 MIMA, Shunsuke; JP
Priority Data:
2017-07616206.04.2017JP
Title (EN) HYDROPHILIC COLORING CELLULOSE MICROPARTICLES
(FR) MICROPARTICULES HYDROPHILES DE CELLULOSE POUVANT SE COLORER
(JA) 親水化着色セルロース微粒子
Abstract:
(EN) Provided are: a coloring cellulose microparticle enabling false positive to be significantly reduced while maintaining a high detection sensitivity; and an immunochromatographic diagnostic kit using the same. The present invention provides: a coloring cellulose microparticle characterized in that an average particle diameter is 60-900 nm, a coloring intensity is 1.0-10.0, and a hydrophilic layer is provided on the surface of microparticle, and a carboxyl group is introduced onto the surface of the microparticle with a spacer therebetween; a structure in which a ligand is covalently bonded to the carboxyl group of said coloring cellulose microparticle; and an immunochromatographic diagnostic kit including said structure.
(FR) L'invention concerne : une microparticule de cellulose pouvant se colorer assurant une réduction significative des faux positifs tout en conservant une sensibilité de détection élevée ; et un kit de diagnostic immunochromatographique l'utilisant. La présente invention concerne : une microparticule de cellulose pouvant se colorer caractérisée en ce que le diamètre de particule moyen varie de 60 à 900 nm, en ce que l'intensité de coloration varie de 1,0 à 10,0, en ce qu'une couche hydrophile est disposée sur la surface de la microparticules et en ce qu'un groupe carboxyle est introduit à la surface de la microparticule avec un espaceur entre les deux ; une structure dans laquelle un ligand est lié de manière covalente au groupe carboxyle de ladite microparticule de cellulose pouvant se colorer ; et un kit de diagnostic immunochromatographique comprenant ladite structure.
(JA) 高い検出感度を維持しながら、偽陽性を大幅に低減することができる着色セルロース微粒子、これを用いたイムノクロマト診断キットの提供。平均粒子径が60~900nmであり、発色強度が1.0~10.0であり、微粒子表面に親水層を有し、かつ、微粒子表面にスペーサーを介してカルボキシル基が導入されていることを特徴とする着色セルロース微粒子、該着色セルロース微粒子のカルボキシル基にリガンドが共有結合されている構造体、及び該構造体を含むイムノクロマト診断キット。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)