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|1. (WO2018186032) FUNCTION INHIBITOR OF SWI/SNF COMPLEXES|
|Applicants:||NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
|Title:||FUNCTION INHIBITOR OF SWI/SNF COMPLEXES|
The present invention provides an anticancer agent based on a novel mechanism. Specifically, the present invention relates to an inhibitor that inhibits gene expression regulation by SWI/SNF complex-dependent NF-κB or corepressor complexes that participate in chromatin remodeling. More specifically, the present invention provides an inhibitor that reduces the interactions (such as binding and transcription regulation) of endogenous SWI/SNF complexes and NF-κB or corepressor complexes or an inhibitor that inhibits the adapter function of d4 family proteins. The inhibitor of the present invention can be utilized in the treatment of cancers involving SWI/SNF complexes (such as SWI/SNF-mediated cancers).