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1. (WO2018186032) FUNCTION INHIBITOR OF SWI/SNF COMPLEXES

Pub. No.:    WO/2018/186032    International Application No.:    PCT/JP2018/005527
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Sat Feb 17 00:59:59 CET 2018
IPC: A61K 45/00
A61K 31/7088
A61K 31/7105
A61K 31/713
A61K 35/76
A61K 38/16
A61K 48/00
A61P 25/00
A61P 35/00
A61P 43/00
Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
国立大学法人千葉大学
Inventors: IBA Hideo
伊庭 英夫
KOBAYASHI Kazuyoshi
小林 和善
Title: FUNCTION INHIBITOR OF SWI/SNF COMPLEXES
Abstract:
The present invention provides an anticancer agent based on a novel mechanism. Specifically, the present invention relates to an inhibitor that inhibits gene expression regulation by SWI/SNF complex-dependent NF-κB or corepressor complexes that participate in chromatin remodeling. More specifically, the present invention provides an inhibitor that reduces the interactions (such as binding and transcription regulation) of endogenous SWI/SNF complexes and NF-κB or corepressor complexes or an inhibitor that inhibits the adapter function of d4 family proteins. The inhibitor of the present invention can be utilized in the treatment of cancers involving SWI/SNF complexes (such as SWI/SNF-mediated cancers).