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1. (WO2018185783) NOVEL PROCESS FOR PREPARATION OF 19-NORSTEROIDS

Pub. No.:    WO/2018/185783    International Application No.:    PCT/IN2018/050196
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Sat Apr 07 01:59:59 CEST 2018
IPC: A61K 31/58
C07J 1/00
C07J 75/00
Applicants: CORAL DRUGS PVT. LTD.
Inventors: TRIPATHI, Vinayak
KUMAR, Rajesh
BHUWANIA, Rohit
BHUWANIA, Binay Kumar
Title: NOVEL PROCESS FOR PREPARATION OF 19-NORSTEROIDS
Abstract:
The present invention provides a single pot process for the synthesis of 19-Norethisterone of Formula (I), comprising contacting 19-Norandostene-3,17-dione of Formula–II with a first base, an organic gas/solution and an acid to obtain 19- Norethisterone of Formula-I; and purifying the 19- Norethisterone of Formula-I thus obtained by refluxing and subsequently washing with organic solvent.