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1. (WO2018185760) EX-VIVO CULTURE SYSTEM AND METHODS OF USING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/185760 International Application No.: PCT/IL2018/050390
Publication Date: 11.10.2018 International Filing Date: 03.04.2018
IPC:
C12N 5/07 (2010.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD.[IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot, IL
Inventors: STRAUSSMAN, Ravid; IL
GAVERT, Nancy; IL
Agent: EHRLICH, Gal; IL
WATERMAN, Hadassa; IL
MELNICK, Geoffrey, L.; IL
Priority Data:
62/481,73805.04.2017US
Title (EN) EX-VIVO CULTURE SYSTEM AND METHODS OF USING SAME
(FR) SYSTÈME DE CULTURE EX-VIVO ET PROCÉDÉS D'UTILISATION DE CELUI-CI
Abstract:
(EN) Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50 % oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.
(FR) Systèmes de culture ex vivo. Système de culture comprenant un milieu de culture et une tranche de tissu coupée précisément placée sur un insert de culture de tissu, la tranche de tissu coupée précisément étant maintenue dans une atmosphère hautement oxygénée contenant au moins 50 % d'oxygène et ladite culture étant agitée en rotation pour faciliter une immersion intermittente de la tranche de tissu dans le milieu de culture. L'invention concerne également des procédés de culture d'un tissu et des procédés d'utilisation du système de culture pour sélectionner un médicament pour le traitement d'une maladie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)