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1. (WO2018185634) ENGINEERED GRAM-NEGATIVE ENDOLYSINS

Pub. No.:    WO/2018/185634    International Application No.:    PCT/IB2018/052253
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Tue Apr 03 01:59:59 CEST 2018
IPC: C12N 9/52
Applicants: SASINAPAS CO., LTD.
Inventors: GRIESSL, Martin
BIEBL, Manfred
Title: ENGINEERED GRAM-NEGATIVE ENDOLYSINS
Abstract:
The present invention relates in general to the field of antimicrobial enzymes. In particular, the present invention relates to a polypeptide comprising the amino acid sequence of a globular Gram-negative endolysin and the amino acid sequence of a cell wall binding domain of i) a modular Gram-negative endolysin or ii) a bacteriophage tail/baseplate protein. The present invention relates also to corresponding nucleic acids, vectors, bacteriophages, host cells, and compositions. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, bacteriophages, host cells, and compositions in methods for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body. The polypeptides, nucleic acids, vectors, bacteriophages, host cells, and compositions according to the invention may also be used as an antimicrobial in, e.g., food or feed, in cosmetics, or as disinfecting agent.