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1. (WO2018185496) CONTROLLED EXCITATION AND SATURATION OF MAGNETISATION TRANSFER SYSTEMS
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Pub. No.: WO/2018/185496 International Application No.: PCT/GB2018/050929
Publication Date: 11.10.2018 International Filing Date: 06.04.2018
IPC:
G01R 33/50 (2006.01) ,G01R 33/56 (2006.01) ,G01R 33/561 (2006.01)
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
44
using nuclear magnetic resonance (NMR)
48
NMR imaging systems
50
based on the determination of relaxation times
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
44
using nuclear magnetic resonance (NMR)
48
NMR imaging systems
54
Signal processing systems, e.g. using pulse sequences
56
Image enhancement or correction, e.g. subtraction or averaging techniques
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
44
using nuclear magnetic resonance (NMR)
48
NMR imaging systems
54
Signal processing systems, e.g. using pulse sequences
56
Image enhancement or correction, e.g. subtraction or averaging techniques
561
by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
Applicants: KING'S COLLEGE LONDON[GB/GB]; Strand London WC2R 2LS, GB
Inventors: TEIXEIRA, Rui Pedro Azeredo Gomes; GB
HAJNAL, Joseph Vilmos; GB
MALIK, Shaihan Jalal; GB
WEST, Daniel John; GB
Agent: WITHERS & ROGERS LLP; 4 More London Riverside London SE1 2AU, GB
Priority Data:
1705577.306.04.2017GB
Title (EN) CONTROLLED EXCITATION AND SATURATION OF MAGNETISATION TRANSFER SYSTEMS
(FR) EXCITATION ET SATURATION CONTRÔLÉES DE SYSTÈMES DE TRANSFERT D'AIMANTATION
Abstract:
(EN) The present invention relate to a system and associate method of MRI and MR spectroscopy which provide stable measurements of the relaxation times, T1 and T2, by using tailored RF pulses that direct control of the saturation conditions in the background pool of macro-molecular protons, and hence provide a flexible means to induce constant Magnetisation Transfer (MT) effects. In doing this, equal saturation of the background pool is obtained for all measurements independent of the parameters that may be changed, for example, the rotation rate used to obtain a desired flip angle, that is, the degree of change in the magnetisation of the free pool of protons.
(FR) La présente invention concerne un système et un procédé associé d'IRM et de spectroscopie par résonance magnétique qui fournissent des mesures stables des temps de relaxation, T1 et T2, en utilisant des impulsions RF sur mesure qui commandent directement les conditions de saturation dans le groupe d'arrière-plan de protons macro-moléculaires, et fournissent donc un moyen flexible pour induire des effets de transfert d'aimantation constante (MT). De cette manière, une saturation égale du groupe d'arrière-plan est obtenue pour toutes les mesures indépendantes des paramètres qui peuvent être modifiés, par exemple, le taux de rotation utilisé pour obtenir un angle de bascule souhaité, c'est-à-dire le degré de variation de l'aimantation du groupe libre de protons.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)