WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018185341) REGULATOR OF BMP-SMAD SIGNALING AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/185341 International Application No.: PCT/EP2018/059040
Publication Date: 11.10.2018 International Filing Date: 09.04.2018
IPC:
A61K 38/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
Applicants: OSPEDALE SAN RAFFAELE S.R.L.[IT/IT]; Via Olgettina 60 20132 Milan (MI), IT
FONDAZIONE CENTRO SAN RAFFAELE[IT/IT]; Via Olgettina 60 20132 Milano (MI), IT
Inventors: SILVESTRI, Laura; IT
CAMASCHELLA, Clara; IT
NAI, Antonella; IT
COLUCCI, Silvia; IT
PAGANI, Alessia; IT
Agent: TRILLAT, Anne-Cécile; IT
CAPASSO, Olga; IT
TURRI, Elisa; IT
Priority Data:
6248317207.04.2017US
Title (EN) REGULATOR OF BMP-SMAD SIGNALING AND USES THEREOF
(FR) RÉGULATEUR DE SIGNALISATION DE BMP-SMAD ET SES UTILISATIONS
Abstract:
(EN) The present invention relates to a regulator of the BMP-SMAD signaling for use in the treatment and/or prevention of a disease selected from the group consisting of: a disease characterized by ineffective erythropoiesis, anemia, a disease characterized by low hepcidin and by iron overload or a combination thereof. Preferably said regulator is an inhibitor of erythroid TFR2 or an inhibitor of hepatocyte FKBP12 or a combination thereof. The present invention also refers to relative pharmaceutical compositions and uses thereof.
(FR) La présente invention concerne un régulateur de la signalisation de BMP-SMAD destiné à être utilisé dans le traitement et/ou la prévention d'une maladie choisie dans le groupe constitué par: une maladie caractérisée par une érythropoïèse inefficace, une anémie, une maladie caractérisée par une faible hepcidine et par une surcharge en fer ou une combinaison de celles-ci. De préférence, ledit régulateur est un inhibiteur de l'érythroïde TFR2 ou un inhibiteur de l'hépatocyte FKBP12 ou une combinaison de ceux-ci. La présente invention concerne également des compositions pharmaceutiques relatives et leurs utilisations.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)