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1. (WO2018185290) USE OF A LIPOSOME ENCAPSULATING A SUGAR COMPOUND IN CEST IMAGING

Pub. No.:    WO/2018/185290    International Application No.:    PCT/EP2018/058869
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Sat Apr 07 01:59:59 CEST 2018
IPC: A61K 49/10
A61K 49/18
A61P 35/00
A61P 3/10
Applicants: UCL BUSINESS PLC
Inventors: GOLAY, Xavier
TABOR, Alethea
STORY, Harriet
DEMETRIOU, Eleni
HAILES, Helen
BOFINGER, Robin
Title: USE OF A LIPOSOME ENCAPSULATING A SUGAR COMPOUND IN CEST IMAGING
Abstract:
The invention provides agents for use in methods of saturation transfer mediated imaging (such as CEST imaging) in a subject, which agents comprise a liposome encapsulating a suitable sugar compound. The disclosure provides novel liposome formulations, which can be used for diagnostic and theranostic purposes. The liposomes can be shielded and\or targeted to a sugar uptake site such as a tumour. The invention has particular utility in modulating the glycaemic response to the encapsulated sugar compound in the subject.