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1. (WO2018185270) MICRORNA 19A/19B FOR USE IN TREATING A PATHOLOGICAL CONDITION ASSOCIATED WITH BONE LOSS OR REDUCED MUSCLE FUNCTION

Pub. No.:    WO/2018/185270    International Application No.:    PCT/EP2018/058828
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Sat Apr 07 01:59:59 CEST 2018
IPC: A61K 31/711
A61K 45/06
A61K 38/29
A61P 19/08
A61P 19/10
Applicants: UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF
Inventors: HESSE, Eric
TAIPALEENMÄKI, Hanna
SAITO, Hiroaki
Title: MICRORNA 19A/19B FOR USE IN TREATING A PATHOLOGICAL CONDITION ASSOCIATED WITH BONE LOSS OR REDUCED MUSCLE FUNCTION
Abstract:
The invention relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with bone loss, in particular osteoporosis and osteogenesis imperfect (01). The inhibitors are also useful for inducing an anabolic effect in bone, either alone or when administered in combination with parathyroid hormone or a recombinant fragment thereof. The invention further relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with reduced muscle function, in particular muscle degeneration and muscle atrophy. The inhibitors are also useful for stabilizing and/or strengthening muscle function. In addition, inhibitors of microRNAs 19a and 19b can be used for treating or preventing cancer-related bone destruction or bone metastasis.