Search International and National Patent Collections

1. (WO2018185244) C4BP-BASED COMPOUNDS FOR TREATING IMMUNOLOGICAL DISEASES

Pub. No.:    WO/2018/185244    International Application No.:    PCT/EP2018/058773
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Fri Apr 06 01:59:59 CEST 2018
IPC: A61K 38/17
A61K 35/15
C07K 14/47
G01N 33/50
A61P 37/06
A61K 39/00
Applicants: FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL)
SPHERIUM BIOMED, S.L.
Inventors: ARAN PERRAMON, Josep M.
RUIZ ÁVILA, Luis Antonio
ORTIZ SAGRISTÀ, Jordi
LLUCH LAFUENTE, Nuria
Title: C4BP-BASED COMPOUNDS FOR TREATING IMMUNOLOGICAL DISEASES
Abstract:
The invention relates to compounds for use in the prevention and/or treatment of immunological diseases, particularly rheumatoid arthritis systemic lupus erythematosus and lupus nephritis, characterized by the subcutaneous administration of isoforms of C4BP lacking the beta chain or polypeptides comprising the CCP6 region of the alpha chain of C4BP no more than once a week or at a dose ranging from 0.24 mg/m2 to 9.99 mg/m2. The invention also relates to pharmaceutical compositions comprising from 0.45 mg to 18.90 mg of said compounds for the prevention and/or treatment of said diseases.