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|1. (WO2018185244) C4BP-BASED COMPOUNDS FOR TREATING IMMUNOLOGICAL DISEASES|
|Applicants:||FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL)
SPHERIUM BIOMED, S.L.
|Inventors:||ARAN PERRAMON, Josep M.
RUIZ ÁVILA, Luis Antonio
ORTIZ SAGRISTÀ, Jordi
LLUCH LAFUENTE, Nuria
|Title:||C4BP-BASED COMPOUNDS FOR TREATING IMMUNOLOGICAL DISEASES|
The invention relates to compounds for use in the prevention and/or treatment of immunological diseases, particularly rheumatoid arthritis systemic lupus erythematosus and lupus nephritis, characterized by the subcutaneous administration of isoforms of C4BP lacking the beta chain or polypeptides comprising the CCP6 region of the alpha chain of C4BP no more than once a week or at a dose ranging from 0.24 mg/m2 to 9.99 mg/m2. The invention also relates to pharmaceutical compositions comprising from 0.45 mg to 18.90 mg of said compounds for the prevention and/or treatment of said diseases.