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1. (WO2018185131) OLIGOMER EXTENDED INSULIN-FC CONJUGATES

Pub. No.:    WO/2018/185131    International Application No.:    PCT/EP2018/058550
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Thu Apr 05 01:59:59 CEST 2018
IPC: A61K 47/68
A61K 47/64
A61P 5/50
A61K 38/28
Applicants: NOVO NORDISK A/S
Inventors: TAGMOSE, Tina, Møller
MADSEN, Peter
KJELDSEN, Thomas, Børglum
PRIDAL, Lone
DE MARIA, Leonardo
LIN, Zhaosheng
WAN, Zhe
ZHANG, Yuanyuan
LYKKE, Lennart
MÜNZEL, Martin, Werner, Borchsenius
KODRA, János, Tibor
Title: OLIGOMER EXTENDED INSULIN-FC CONJUGATES
Abstract:
This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.