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1. (WO2018184965) IMMUNOCONJUGATES OF IL-2 WITH AN ANTI-PD-1 AND TIM-3 BISPECIFIC ANTIBODY

Pub. No.:    WO/2018/184965    International Application No.:    PCT/EP2018/058037
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: C07K 14/55
A61K 38/20
C07K 16/28
A61K 39/00
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: CODARRI DEAK, Laura
KLEIN, Christian
LAUENER, Laura
SEEBER, Stefan
UMAÑA, Pablo
WALDHAUER, Inja
Title: IMMUNOCONJUGATES OF IL-2 WITH AN ANTI-PD-1 AND TIM-3 BISPECIFIC ANTIBODY
Abstract:
The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.