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1. (WO2018184678) HDAC INHIBITOR IN COMBINATION WITH VEGF / VEGFR INTERACTION INHIBITOR FOR CANCER THERAPY BASED ON PLATELET COUNT

Pub. No.:    WO/2018/184678    International Application No.:    PCT/EP2017/058157
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Thu Apr 06 01:59:59 CEST 2017
IPC: A61K 31/40
A61K 31/44
A61P 35/00
A61K 45/06
Applicants: 4SC AG
Inventors: KRAUSS, Rolf
KIMURA, Takuya
KUDO, Masatoshi
Title: HDAC INHIBITOR IN COMBINATION WITH VEGF / VEGFR INTERACTION INHIBITOR FOR CANCER THERAPY BASED ON PLATELET COUNT
Abstract:
The invention relates to methods, composition and uses for the of treatment of cancer selected from the group consisting of HCC, RCC, NSCLC, ovarian cancer, CCA, PTC and FTC in a subject, which comprise administering an HDAC inhibitor in combination with a compound inhibiting the VEGF / VEGFR interaction, wherein said subject is characterized in having a platelet count of about 140000 platelets/μΙ or higher.