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1. (WO2018184590) [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR
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Pub. No.: WO/2018/184590 International Application No.: PCT/CN2018/082119
Publication Date: 11.10.2018 International Filing Date: 08.04.2018
IPC:
C07D 487/04 (2006.01) ,A61K 31/505 (2006.01) ,A61K 31/519 (2006.01) ,A61P 25/16 (2006.01) ,A61P 43/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants: MEDSHINE DISCOVERY INC.[CN/CN]; Room 218, No.9 Gaoxin Road, Gaoxin Development District Nanjing, Jiangsu 210032, CN
Inventors: CHEN, Xinhai; CN
YU, Yanxin; CN
CHEN, Xinde; CN
ZHANG, Li; CN
CHEN, Zhaoguo; CN
XIE, Cheng; CN
WANG, Xiaofei; CN
WU, Linghui; CN
HU, Guoping; CN
LI, Jian; CN
CHEN, Shuhui; CN
Agent: SHANGHAI BESHINING LAW OFFICE; 21st Floor SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032, CN
Priority Data:
201710224553.907.04.2017CN
201710737871.524.08.2017CN
201810129208.108.02.2018CN
Title (EN) [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR
(FR) DÉRIVÉ DE [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE EN TANT QU'INHIBITEUR DU RÉCEPTEUR A2A
(ZH) 作为A 2A受体抑制剂的[1,2,4]三唑并[1,5-c]嘧啶衍生物
Abstract:
(EN) Provided are a compound represented by formula (I), an isomer or a pharmaceutically acceptable salt thereof, and an application of the same in preparing a drug for treating a disease related to A2A receptor. The R1, R2, R3, ring A, ring B, n, and m are as defined in the specification.
(FR) L'invention concerne un composé représenté par la formule (I), un isomère ou un sel pharmaceutiquement acceptable de celui-ci, et une application dudit composé dans la préparation d'un médicament pour le traitement d'une maladie liée à un récepteur A2A. Dans la formule, R1, R2, R3, cycle A, cycle B, n et m sont tels que définis dans la description.
(ZH) 式(Ⅰ)所示化合物、其异构体或其药学上可接受的盐,以及其在制备治疗与A 2A受体相关疾病药物中的应用,其中R 1、R 2、R 3、环A、环B、n和m为如本文中定义的。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)