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1. (WO2018184188) RECOMBINANT BCG OVEREXPRESSING phoP-phoR

Pub. No.:    WO/2018/184188    International Application No.:    PCT/CN2017/079665
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Sat Apr 08 01:59:59 CEST 2017
IPC: C12N 1/21
C12N 15/31
C07K 14/35
Applicants: LIU, Jun
CHENGDU YONGAN PHARMACEUTICAL CO., LTD.
Inventors: LIU, Jun
Title: RECOMBINANT BCG OVEREXPRESSING phoP-phoR
Abstract:
Provided are a live recombinant Mycobacterium bovis-BCG strain and a tuberculosis (TB) vaccine or immunogenic composition comprising a nucleic acid capable of overexpression, the nucleic acid encoding PhoP and PhoR proteins. A method for treatment or prophylaxis of a mammal against challenge by Mycobacterium tuberculosis or Mycobacterium bovis using the strain is also provided.