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1. (WO2018184115) QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING

Pub. No.:    WO/2018/184115    International Application No.:    PCT/CA2018/050425
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Sat Apr 07 01:59:59 CEST 2018
IPC: C07D 417/14
A61K 31/517
A61K 49/00
A61K 51/04
A61P 5/06
C07D 401/14
C07D 417/06
G01N 33/53
G01N 33/574
G01N 33/58
Applicants: LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
Inventors: LUYT, Leonard G.
HOU, Jinqiang
Title: QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING
Abstract:
Compounds comprising quinazolinone derivatives and methods of identification and use of imaging agents. The compounds have the general formula I: wherein R2 is selected from halogen, halosubstituted alkyl, alkyl, hydroxyl-alkyl, and amino-alkyl; X is selected from ester, carbonyl or -CH2-; R1 is selected from mono-, or bicyclic aromatic or heteroaromatic ring systems, wherein the mono-, or bicyclic aromatic or heteroaromatic ring systems are optionally substituted by halo, alkyl, nitro, alkoxy, amino; R3 is selected from one or two halo, halosubstituted alkyl, alkyl, nitro, hydroxyl- alkyl, and alkyl tosylate; or a pharmaceutically acceptable salt thereof. The compounds of the present invention may be used for detection, diagnosis and/or staging of prostate or other forms of cancer, and may also be used for cardiac disease.