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1. (WO2018184073) A METHOD FOR TESTING ANTIMICROBIAL SUSCEPTIBILITY

Pub. No.:    WO/2018/184073    International Application No.:    PCT/AU2018/050318
Publication Date: Fri Oct 12 01:59:59 CEST 2018 International Filing Date: Sat Apr 07 01:59:59 CEST 2018
IPC: C12Q 1/18
C12Q 1/02
C12Q 1/06
G01N 15/14
Applicants: THE UNIVERSITY OF WESTERN AUSTRALIA
Inventors: INGLIS, Timothy John Jay
MULRONEY, Kieran
HALL, Jarrad
Title: A METHOD FOR TESTING ANTIMICROBIAL SUSCEPTIBILITY
Abstract:
The present invention relates to methods for the qualitative and quantitative determination of the susceptibility of microbial organisms such as bacteria to antimicrobial agents such as antibiotics. For example, the present invention provides a method of determining the susceptibility of a unicellular or multicellular microorganism to an antimicrobial agent by acoustic flow cytometry. The method comprising exposing cells of the microorganism to at least one antimicrobial agent, wherein said cells of the microorganism are in and/or derived from a sample obtained from a subject having or suspected of having an infection with said microorganism; measuring effect of said at least one antimicrobial agent on cellular morphology of said cells of the microorganism by acoustic flow cytometry; and determining susceptibility of the microorganism to the at least one antimicrobial agent from the acoustic flow cytometry data output.