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1. WO2018183956 - NAPHTHYRIDINES AS INHIBITORS OF HPK1

Publication Number WO/2018/183956
Publication Date 04.10.2018
International Application No. PCT/US2018/025562
International Filing Date 30.03.2018
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61K 31/4375 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/4375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/444
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
444containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
A61K 31/4545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
4545containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/4725
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 31/5025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
Applicants
  • GENENTECH, INC. [US]/[US] (US)
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
Inventors
  • CHAN, Bryan
  • DANIELS, Blake
  • DROBNICK, Joy
  • GAZZARD, Lewis
  • HEFFRON, Timothy
  • HUESTIS, Malcolm
  • LIANG, Jun
  • MALHOTRA, Sushant
  • MENDONCA, Rohan
  • RAJAPAKSA, Naomi
  • SIU, Michael
  • STIVALA, Craig
  • TELLIS, John
  • WANG, Weiru
  • WEI, BinQing
  • ZHOU, Aihe
  • CARTWRIGHT, Matthew W.
  • GANCIA, Emanuela
  • JONES, Graham
  • LAINCHBURY, Michael
  • MADIN, Andrew
  • SEWARD, Eileen
  • FAVOR, David
  • FONG, Kin Chiu
  • HU, Yonghan
  • GOOD, Andrew
  • HU, Baihua
  • LU, Aijun
Agents
  • TIAN, Zong-Qiang Bill
  • ACKERMAN, Lily J.
  • AUSENHUS, Scott L.
  • BERENDT, Frank JN
  • BUCKWALTER, Brian L.
  • CHANG, Y. Elaine
  • CHI, I. Shannon
  • CLARK, Kevin M.
  • COBURN, Cara M.
  • COLANTINO, Jessica R.
  • CRISSEY, Todd M.
  • CUI, Steven
  • DAVIS, Jennifer L.
  • DUFFIELD, Jonathan J.
  • FANG, Carol A.
  • GHOSE, Shameek
  • HALL, Robert C.
  • HEIDER, Julie A.
  • HILL, Laurie L.
  • HOLMES, Jennifer K.
  • JOHNSTON, Sean A.
  • KAFKA, Mark D.
  • KALE, Tamara A.
  • KALINOWSKI, Grant E.
  • KUBINEC, Jeffrey S.
  • LEE, Wendy M.
  • LI, Qianru
  • MARSCHANG, Diane L.
  • MCCLELLAN, Kelly B.
  • PAZDERA, R. Minako
  • RICHARDSON, Jessica L.
  • ROPP, Traci H.
  • SCHWARTZ, Timothy R.
  • SHERMAN, Daniel E.
  • SHIN, Elinor K.
  • TAN, Anna M.
  • WAIS, Rebecca J.
  • YEUNG, Bonny G.
  • DREGER, Ginger
Priority Data
PCT/CN2017/07879230.03.2017CN
PCT/CN2018/07690915.02.2018CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NAPHTHYRIDINES AS INHIBITORS OF HPK1
(FR) NAPHTYRIDINES UTILISÉS EN TANT QU'INHIBITEURS DE HPK1
Abstract
(EN)
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
(FR)
L'invention concerne des composés de naphtyridine et leur utilisation en tant qu'inhibiteurs de HPK1. Les composés de l'invention sont utiles dans le traitement de troubles dépendant de HPK1 et l'amélioration d'une réponse immunitaire. L'invention concerne également des procédés d'inhibition de HPK1, des procédés de traitement de troubles dépendant de HPK1, des procédés d'amélioration d'une réponse immunitaire, et des procédés de préparation des composés de naphtyridine.
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