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1. (WO2018183944) COMPOSITIONS FOR THE TREATMENT OF DRUG-RESISTANT TUMORS AND METHODS OF USE THEREOF
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Pub. No.: WO/2018/183944 International Application No.: PCT/US2018/025544
Publication Date: 04.10.2018 International Filing Date: 30.03.2018
IPC:
A61K 31/138 (2006.01) ,A61K 31/15 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/352 (2006.01) ,A61K 31/353 (2006.01) ,A61K 31/423 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
138
Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
15
Oximes (CN-O-); Hydrazines (N-N); Hydrazones (N-N)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42
Oxazoles
423
condensed with carbocyclic rings
Applicants:
THE CURATORS OF THE UNIVERSITY OF MISSOURI [US/US]; 316 University Hall Columbia, Missouri 65211, US
Inventors:
KANNAN, Raghuraman; US
DHANANJAY, Suresh; US
MUKHERJEE, Soumavo; US
ZAMBRE, Ajit P.; US
UPENDRAN, Anandhi; US
Agent:
HOLTZ, William A.; US
BLUM, Anthony F.; US
BRAUNEL, Matthew A.; US
COLVIN, Katherine E.; US
DAVIS, J. Wendy; US
GERLACH, Robert D.; US
HIMICH, Matthew J.; US
RITCHEY, Steven M.; US
JINKINS, David B.; US
KERCHER, Kevin M.; US
MANSE, Jared S.; US
MOUSSAVI, Sartouk H.; US
MUSCH, Jonathan G.; US
NEPPLE, Michael L.; US
NORMAN, Alan H.; US
PARKS, Michael A.; US
POLCYN, Thomas A.; US
BLENKE, Thaddeus J.; US
ROMANO, Charles P.; US
SCHWENT, Jason M.; US
VOLK, JR., Benjamin L.; US
ZAK, Clayton R.; US
Priority Data:
62/479,93131.03.2017US
Title (EN) COMPOSITIONS FOR THE TREATMENT OF DRUG-RESISTANT TUMORS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS POUR LE TRAITEMENT DE TUMEURS RÉSISTANT AUX MÉDICAMENTS ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) Provided herein are methods and compositions for sensitizing a cancer cell to a cancer treatment, for example to an anticancer drug by the inhibition of at least two cancer biomarkers. Further provided are methods of treating and/or preventing a cancer including reducing the size of a tumor. Also provided are compositions comprising nanoparticles associated with inhibitory molecules, such as siRNA, and/or anticancer drugs.
(FR) L'invention concerne des procédés et des compositions permettant de sensibiliser une cellule cancéreuse à un traitement anticancéreux, par exemple à un médicament anticancéreux par l'inhibition d'au moins deux biomarqueurs du cancer. L'invention concerne en outre des procédés de traitement et/ou de prévention d'un cancer, comprenant la réduction de la taille d'une tumeur. L'invention concerne également des compositions comprenant des nanoparticules associées à des molécules inhibitrices, telles que l'ARNsi, et/ou des médicaments anticancéreux.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)