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1. (WO2018183889) ANTI-TIGIT ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/183889    International Application No.:    PCT/US2018/025460
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Sat Mar 31 01:59:59 CEST 2018
IPC: C07K 16/22
C07K 16/28
A61K 39/00
Applicants: POTENZA THERAPEUTICS, INC.
STEINER, Philipp
Inventors: STEINER, Philipp
NIELSON, Nels, P.
HICKLIN, Daniel
SEIDEL-DUGAN, Cynthia
WINSTON, William
BRODKIN, Heather
SALMERON-GARCIA, Jose-Andres
NIRSCHL, Christopher, James
Title: ANTI-TIGIT ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF
Abstract:
Provided herein are antigen-binding proteins (ABPs) that selectively bind to TIGIT and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.