Search International and National Patent Collections

1. (WO2018183857) PIPERIDINES AS COVALENT MENIN INHIBITORS

Pub. No.:    WO/2018/183857    International Application No.:    PCT/US2018/025417
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Sat Mar 31 01:59:59 CEST 2018
IPC: A61K 31/445
C07D 211/26
C07D 401/06
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: WANG, Shaomeng
AGUILAR, Angelo
XU, Shilin
HUANG, Liyue
STUCKEY, Jeanne
TIANFENG, Xu
Title: PIPERIDINES AS COVALENT MENIN INHIBITORS
Abstract:
The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, R1a, R1b, R1c, R1d, R2, R3, R8a, R8b, R10, X, Z2, m, and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer.