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1. (WO2018183850) METHODS, SYSTEMS, AND COMPOSITIONS FOR INHIBITING VIRULANCE OF A/E FAMILY PATHOGENS

Pub. No.:    WO/2018/183850    International Application No.:    PCT/US2018/025408
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Sat Mar 31 01:59:59 CEST 2018
IPC: A61K 39/02
A61K 38/16
Applicants: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventors: VISWANATHAN, Virinchipuram, K.
VEDANTAM, Gayatri
Title: METHODS, SYSTEMS, AND COMPOSITIONS FOR INHIBITING VIRULANCE OF A/E FAMILY PATHOGENS
Abstract:
The present invention features methods, systems, and compositions for inhibiting function of EspZ or an EspZ equivalent, and for inhibiting or reducing virulence of pathogens that utilize EspZ or EspZ equivalent, such as those pathogens that belong to the attaching-effacing (A/E) family. The methods may feature the use of an inhibitor peptide that targets at least a portion of EspZ, such as one of the transmembrane domains. In certain embodiments, the inhibitor peptide disrupts proper dimerization or oligomerization of EspZ.