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1. (WO2018183796) SYSTEMS AND METHODS FOR PREDICTING AND MONITORING CANCER THERAPY

Pub. No.:    WO/2018/183796    International Application No.:    PCT/US2018/025335
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Sat Mar 31 01:59:59 CEST 2018
IPC: A61K 39/395
C07H 21/04
C12N 15/10
C12Q 1/68
C40B 40/06
G01N 33/574
Applicants: PREDICINE, INC.
Inventors: ZHAO, Zhixin
JIA, Shidong
DU, Pan
Title: SYSTEMS AND METHODS FOR PREDICTING AND MONITORING CANCER THERAPY
Abstract:
Disclosed are systems and methods for diagnosing a disease status or progression of a disease comprising detection and correlation of methylation and expression level changes of cancer markers including PD-L1 in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection and correlation of methylation and expression level changes in solid tissues. The present method utilized a barcoding method for analysis. The systems and methods can be used for predicting immunotherapy resistant cancer and monitoring therapy response.