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1. (WO2018183782) 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/183782 International Application No.: PCT/US2018/025304
Publication Date: 04.10.2018 International Filing Date: 29.03.2018
IPC:
C07D 487/14 (2006.01) ,A61P 29/00 (2006.01) ,A61K 31/519 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
Applicants: SITEONE THERAPEUTICS, INC.[US/US]; 203 Enterprise Blvd., Suite 3 Bozeman, Montana 59718, US
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY[US/US]; Office of the General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, California 94305-2038, US
Inventors: MULCAHY, John; US
PAJOUHESH, Hassan; US
MILJANICH, George; null
DELWIG, Anton; US
BECKLEY, Jacob; US
SHIBUYA, Grant Masaaki; US
DU BOIS, Justin; US
Agent: PATHAK, Rahul; US
LIU, Qun; US
RICE, Janice; US
KERRIGAN, Cameron; US
REED, James; US
MORALES, Norman L.; US
OSTOMEL, Todd; US
LAI, Karen; US
SAHASRABUDHE, Kiran; US
GUSLER, Gloria; US
NOSON, Kevin; US
Priority Data:
62/478,51929.03.2017US
Title (EN) 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN
(FR) SAXITOXINES 11,13-MODIFIÉES DESTINÉES AU TRAITEMENT DE LA DOULEUR
Abstract:
(EN) Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R1, X1, and X2 are as described herein.
(FR) La présente invention concerne des composés, des compositions pharmaceutiques comprenant les composés, des procédés de préparation des composés, et des procédés d'utilisation des composés et des compositions dans le traitement d'états pathologiques associés à la fonction de canal sodique dépendant de la tension. Les composés de l'invention sont des saxitoxines 11,13-modifiées selon la Formule (I) : dans laquelle, R1, X1 et X2 sont tels que décrits dans la description.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)