Search International and National Patent Collections

1. (WO2018183746) SYSTEMS AND METHODS FOR USE IN IDENTIFYING MULTIPLE GENOME EDITS AND PREDICTING THE AGGREGATE EFFECTS OF THE IDENTIFIED GENOME EDITS

Pub. No.:    WO/2018/183746    International Application No.:    PCT/US2018/025250
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: G06F 19/18
C12N 15/79
A01K 67/027
Applicants: MONSANTO TECHNOLOGY LLC
Inventors: BUTRUILLE, David Vincent
FLAGEL, Lex Evan
Title: SYSTEMS AND METHODS FOR USE IN IDENTIFYING MULTIPLE GENOME EDITS AND PREDICTING THE AGGREGATE EFFECTS OF THE IDENTIFIED GENOME EDITS
Abstract:
Exemplary systems and methods for selecting from population of candidate edits and predicting an aggregate effect of the candidate edits are disclosed. One exemplary method includes identifying a population of candidate edits to a genomic sequence of said organism and ranking each of the candidate edits based on a predicted ability of each candidate edit to affect a trait of interest in said organism. The exemplary method further includes selecting one or more of the candidate edits based on the ranking and predicting, by the computing device, an aggregate effect of the selected one or more of the candidate edits for the trait of interest when expressed by a specimen of the organism having a genomic sequence and edited according to the selected one or more of the candidate edits, as compared to an unedited specimen of the organism.