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1. (WO2018183703) LYMPHOCYTE-BASED MORPHOMETRIC TEST FOR ALZHEIMER'S DISEASE
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Pub. No.: WO/2018/183703 International Application No.: PCT/US2018/025179
Publication Date: 04.10.2018 International Filing Date: 29.03.2018
IPC:
A61B 5/055 (2006.01) ,A61B 6/03 (2006.01) ,A61B 8/08 (2006.01)
[IPC code unknown for A61B 5/055][IPC code unknown for A61B 6/03][IPC code unknown for A61B 8/08]
Applicants:
NEURODIAGNOSTICS LLC [US/US]; 9601 Medical Drive, Suite 3 Rockville, Maryland 20850, US
Inventors:
CHIRILA, Florin Valentin; US
ALKON, Daniel L.; US
Agent:
MORRISON, Alan J.; US
Priority Data:
62/479,63031.03.2017US
Title (EN) LYMPHOCYTE-BASED MORPHOMETRIC TEST FOR ALZHEIMER'S DISEASE
(FR) TEST MORPHOMÉTRIQUE BASÉ SUR LES LYMPHOCYTES DÉDIÉ À LA MALADIE D'ALZHEIMER
Abstract:
(EN) This invention provides methods for diagnosing Alzheimer's disease in a symptomatic human subject, and for determining whether a human subject is predisposed to becoming afflicted with Alzheimer's disease. These methods employ the steps of (a) culturing a subject's lymphocytes with a suitable basement membrane matrix to permit the lymphocytes to aggregate; (b) measuring the resulting lymphocyte aggregation; and (c) based on such measurement, either diagnosing Alzheimer's disease or determining a predisposition to it, as appropriate.
(FR) L’invention concerne des méthodes pour diagnostiquer la maladie d'Alzheimer chez un sujet humain symptomatique et pour déterminer si un sujet humain est prédisposé à la maladie d'Alzheimer. Ces méthodes comprennent les étapes consistant à (a) mettre en culture des lymphocytes d'un sujet avec une matrice de membrane basale appropriée pour permettre aux lymphocytes de s'agréger ; (b) mesurer l'agrégation de lymphocytes résultante ; et (c), sur la base d'une telle mesure, soit diagnostiquer la maladie d'Alzheimer, soit déterminer une prédisposition à celle-ci, suivant le cas.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)