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1. (WO2018183664) ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE
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Pub. No.: WO/2018/183664 International Application No.: PCT/US2018/025122
Publication Date: 04.10.2018 International Filing Date: 29.03.2018
IPC:
C12N 9/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
Applicants:
GENOMATICA, INC. [US/US]; 4757 Nexus Center Drive San Diego, CA 92121, US
Inventors:
HOFF, Kevin; US
TRACEWELL, Cara, Ann; US
CHAN, Kui; US
SHAH, Amit; US
WARNER, Joseph; US
NOBLE, Michael; US
Agent:
CADENA, Deborah, L.; US
GAY, David, A.; US
RICH, Roger; US
SPAIN, Astrid; US
WEISSER, Tamera, M.; US
Priority Data:
62/480,19431.03.2017US
Title (EN) ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE
(FR) VARIANTS D'ALDÉHYDE DÉSHYDROGÉNASE ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3 -butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.
(FR) L'invention concerne des polypeptides et des acides nucléiques codants de variants d'aldéhyde déshydrogénase. L'invention concerne également des cellules exprimant des variants d'aldéhyde déshydrogénase. L'invention concerne en outre des procédés pour la production de 3-hydroxybutyraldéhyde (3-HBal) et/ou de butane-1,3-diol (1,3-BDO), ou d'un ester ou amide de ceux-ci, comprenant la culture de cellules exprimant un variant d'aldéhyde déshydrogénase ou l'utilisation de lysats de telles cellules. L'invention concerne en outre des procédés pour la production de 4-hydroxybutyraldéhyde (4-HBal) et/ou de 1,4-butanediol (1,4-BDO), ou d'un ester ou amide de ceux-ci, comprenant la culture de cellules exprimant un variant d'aldéhyde déshydrogénase ou l'utilisation de lysats de telles cellules.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)