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1. (WO2018183661) FORMULATION FOR PROTECTION THROUGH CONTROLLED RELEASE OF MICROPARTICLES CONTAINING RECOMBINANT OUTER MEMBRANE VESICLES

Pub. No.:    WO/2018/183661    International Application No.:    PCT/US2018/025119
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: A61K 38/16
A61K 39/38
A61K 39/015
C12N 15/70
Applicants: CORNELL UNIVERSITY
Inventors: PUTNAM, David
WATKINS, Hannah, C.
DELISA, Matthew, P.
WHITTAKER, Gary, R.
GUARINO, Cassandra
Title: FORMULATION FOR PROTECTION THROUGH CONTROLLED RELEASE OF MICROPARTICLES CONTAINING RECOMBINANT OUTER MEMBRANE VESICLES
Abstract:
The present invention relates to a microparticle. The microparticle includes one or more recombinant outer membrane vesicles, at least some of which display a fusion protein, where the fusion protein comprises at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides, and a polymeric coating over the one or more recombinant outer membrane vesicles. The present invention further relates to a method of eliciting an immune response in a mammal and a method of making encapsulated outer membrane vesicles displaying a fusion protein.