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1. (WO2018183622) MICROFLUIDIC ANALYSIS OF BIOLOGICAL SAMPLES

Pub. No.:    WO/2018/183622    International Application No.:    PCT/US2018/025057
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: G01N 27/447
Applicants: 908 DEVICES INC.
Inventors: MELLORS, J. Scott
Title: MICROFLUIDIC ANALYSIS OF BIOLOGICAL SAMPLES
Abstract:
The disclosure features methods and systems for processing samples that include introducing a sample (360) featuring one or more components in a first electrolyte solution (312) into a separation channel (304) of a fluidic device (300), using electrodes (316,318) for applying an electrical potential difference across the sample to cause migration of at least one sample component toward an end (320) of the separation channel (304), and adjusting at least one of a gas pressure in a reservoir (306) comprising a second electrolyte solution (314), and a gas pressure external to an aperture positioned at the end of the separation channel, so that the gas pressure in the reservoir (306) is greater than the gas pressure external to the aperture, and directing a flow of the second electrolyte solution (314) in response to the gas pressures through the pumping channel (308) and out of the aperture (310) to discharge the at least one sample component including background electrolyte solutions from separation channel and pumping channel (340) through the aperture (310).