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1. (WO2018183613) ANTIBODY-MEDIATED CONDITIONING WITH IMMUNOSUPPRESSION TO ENABLE ALLOGENEIC TRANSPLANTATION

Pub. No.:    WO/2018/183613    International Application No.:    PCT/US2018/025044
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: A61K 35/28
A61K 47/68
C07K 16/28
C07K 16/30
C12N 5/00
Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION
THE GOVERNMENT OF THE UNITED STATES OF AMERICA D. B. A. DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors: ROSSI, Derrick J.
CZECHOWICZ, Agnieszka D.
MURPHY, Philip M.
LI, Zhanzhuo
Title: ANTIBODY-MEDIATED CONDITIONING WITH IMMUNOSUPPRESSION TO ENABLE ALLOGENEIC TRANSPLANTATION
Abstract:
Provided are methods and compositions conditioning a patient for an allogeneic transplantation, wherein the patient's hematopoietic stem cells (HSCs) are depleted with an HSC-depleting composition and the patient is then administered allogeneic cells selected from bone marrow cells, umbilical cord blood cells, hematopoietic stem and progenitor cells (HSPCs), peripheral blood CD34+cells, and peripheral blood CD34+ and CD90+ cells; optionally the patient is also administered a medicament selected from the group consisting of a T-cell depleting or inhibiting antibody or antibody fragment, NK-cell depleting or inhibiting antibody or antibody fragment, immunosuppressive drug, and any combination thereof. The HSC-depleting composition comprises a compound selected from the group consisting of: an antibody or antibody fragment with specific binding affinity to a protein displayed at the HSC surface, a conjugate comprising an HSC-recognition molecule and a toxin, and any combination thereof.