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1. (WO2018183580) COMPOSITIONS AND METHODS FOR TREATMENT OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPARG) ACTIVATED CANCER

Pub. No.:    WO/2018/183580    International Application No.:    PCT/US2018/024970
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Thu Mar 29 01:59:59 CEST 2018
IPC: A61K 35/14
A61K 39/00
A61K 47/48
Applicants: THE BROAD INSTITUTE, INC
DANA-FARBER CANCER INSTITUTE, INC.
Inventors: GOLDSTEIN, Jonathan
MEYERSON, Matthew
STRATHDEE, Craig
Title: COMPOSITIONS AND METHODS FOR TREATMENT OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPARG) ACTIVATED CANCER
Abstract:
The present disclosure provides compositions and methods for the treatment of PPARG activated cancer. For example, the present disclosure provides PPARG signaling modulators for the treatment of bladder cancer. In particular, therapeutic and/or prophylactic compositions and uses of PPARG inverse-agonists are described.