Search International and National Patent Collections

1. (WO2018183551) CHIMERIC POLYPEPTIDES AND METHODS OF ALTERING THEIR LOCALISATION IN THE CELL MEMBRANE

Pub. No.:    WO/2018/183551    International Application No.:    PCT/US2018/024916
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Thu Mar 29 01:59:59 CEST 2018
IPC: C07K 14/725
C07K 14/72
A61K 38/17
Applicants: CELL DESIGN LABS, INC.
Inventors: SANTORO, Stephen
COYLE, Scott
RUPP, Levi
EMTAGE, Peter
Title: CHIMERIC POLYPEPTIDES AND METHODS OF ALTERING THEIR LOCALISATION IN THE CELL MEMBRANE
Abstract:
Methods and compositions are provided for reversibly localizing proteins to the exterior part of the cell surface. Essentially, the protein must comprise, in addition to a transmembrane domain, also a hormone receptor like the estrogen receptor alpha or the progesterone receptor. Compositions provided herein can include nucleic acids that encode polypeptides of interest and the ligand binding domain (LBD) of a nuclear hormone receptor. Medical applications are provided, including controlling the toxicity of CAR T cells.