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1. (WO2018183475) A MULTIPLE ANTIGEN PRESENTING SYSTEM (MAPS)-BASED STAPHYLOCOCCUS AUREUS VACCINE, IMMUNOGENIC COMPOSITION, AND USES THEREOF
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Pub. No.: WO/2018/183475 International Application No.: PCT/US2018/024810
Publication Date: 04.10.2018 International Filing Date: 28.03.2018
IPC:
A61K 39/02 (2006.01) ,C07K 16/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12
against material from bacteria
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION[US/US]; 55 Shattuck Street Boston, Massachusetts 02115, US
Inventors: MALLEY, Richard; US
ZHANG, Fan; US
LU, Yingjie; US
Agent: BENN, Susanna C.; US
RESNICK, David S.; US
EISENSTEIN, Ronald I.; US
FITZGERALD, Mark J.; US
BRAICH, Ravinderjit S.; US
CROSBY, David F.; US
HUFF, Shayne Y.; US
MILLS, Tari W.; US
PTASHKA, Teresa A.; US
SUMMERFORD, Candace M.; US
KLING, Nicole D.; US
Priority Data:
62/477,61828.03.2017US
Title (EN) A MULTIPLE ANTIGEN PRESENTING SYSTEM (MAPS)-BASED STAPHYLOCOCCUS AUREUS VACCINE, IMMUNOGENIC COMPOSITION, AND USES THEREOF
(FR) VACCIN CONTRE LE STAPHYLOCOCCUS AUREUS À BASE DE SYSTÈME DE PRÉSENTATION D'ANTIGÈNES MULTIPLES (MAPS), COMPOSITION IMMUNOGÈNE ET LEURS UTILISATIONS
Abstract:
(EN) The present embodiments provide for an S. aureus (SA) Multiple Antigen Presenting System (MAPS) immunogenic composition comprising an immunogenic polysaccharide which induces an immune response, where at least one S. aureus (SA) peptide or polypeptide antigen is associated to the immunogenic polysaccharide by complementary affinity molecules. In some embodiments, the immunogenic polysaccharide can be an antigenic capsular polysaccharide of a Type 5 or Type 8 from S. aureus, or alternatively, a different immunogenic capsular or noncapsular polysaccharide, and where the protein or peptide SA antigens are indirectly linked via an affinity binding pair. The present SA-MAPS immunogenic compositions can elicit both humoral and cellular immune responses to the immunogenic polysaccharide and one or multiple SA antigens at the same time.
(FR) Les présents modes de réalisation concernent une composition immunogène à système de présentation d'antigènes multiples (MAPS) S. aureus (SA) comprenant un polysaccharide immunogène qui induit une réponse immunitaire, au moins un peptide S. aureus (SA) ou un antigène polypeptidique étant associé au polysaccharide immunogène par des molécules ayant des affinités complémentaires. Selon certains modes de réalisation, le polysaccharide immunogène peut être un polysaccharide capsulaire antigénique d'un Type 5 ou d'un Type 8 issu de S. aureus, ou en variante, un polysaccharide capsulaire ou non capsulaire différent, et les antigènes SA protéiques ou peptidiques étant liés indirectement par le biais d'une paire de liaisons d'affinité. Les présentes compositions immunogènes à MAPS SA peuvent éliciter des réponses immunitaires à la fois humorales et cellulaires au polysaccharide immunogène et à un ou plusieurs antigènes SA en même temps.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)