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1. (WO2018183411) SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
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Pub. No.: WO/2018/183411 International Application No.: PCT/US2018/024708
Publication Date: 04.10.2018 International Filing Date: 28.03.2018
IPC:
C07D 311/68 (2006.01) ,C07D 333/20 (2006.01) ,C07D 417/12 (2006.01) ,C07D 417/14 (2006.01) ,C07D 471/04 (2006.01) ,C07D 471/08 (2006.01) ,C07D 277/28 (2006.01) ,C07D 277/64 (2006.01) ,A61P 11/00 (2006.01) ,A61P 3/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 25/28 (2006.01) ,A61P 29/00 (2006.01) ,A61K 31/426 (2006.01) ,A61K 31/428 (2006.01)
[IPC code unknown for C07D 311/68][IPC code unknown for C07D 333/20][IPC code unknown for C07D 417/12][IPC code unknown for C07D 417/14][IPC code unknown for C07D 471/04][IPC code unknown for C07D 471/08][IPC code unknown for C07D 277/28][IPC code unknown for C07D 277/64][IPC code unknown for A61P 11][IPC code unknown for A61P 3][IPC code unknown for A61P 9][IPC code unknown for A61P 25/28][IPC code unknown for A61P 29][IPC code unknown for A61K 31/426][IPC code unknown for A61K 31/428]
Applicants:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; Office of Technology Transfer 1600 Huron Parkway, 2nd Floor Ann Arbor, MI 48109-2590, US
Inventors:
WANG, Shaomeng; US
ZHOU, Haibin; US
LU, Jianfeng; US
LIU, Liu; US
SUN, Yi; US
BERNARD, Denzil; US
Agent:
NAPOLI, James, J.; US
Priority Data:
62/477,49828.03.2017US
Title (EN) SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
(FR) INHIBITEURS DE DCN1 À PETITES MOLÉCULES ET PROCÉDÉS THÉRAPEUTIQUES LES UTILISANT
Abstract:
(EN) Compounds of formula (I) as inhibitors of DCNl and compositions containing the same are disclosed. Methods of using the DCNl inhibitors in the treatment of diseases and conditions wherein inhibition of DCNl provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.
(FR) L'invention concerne des composés de formule (I) utilisés en tant qu'inhibiteurs de DCNl ainsi que des compositions les contenant. L'invention concerne également des procédés d'utilisation des inhibiteurs de DCNl dans le traitement de maladies et d'états pathologiques dans lesquels l'inhibition de DCNl est bénéfique, tels que des maladies et des états pathologiques liés au stress oxydatif, des maladies et des états pathologiques neurodégénératifs, des troubles métaboliques et une dégénérescence du nerf musculaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)