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1. (WO2018183385) TRUNCATED NKG2D CHIMERIC RECEPTORS AND USES THEREOF IN NATURAL KILLER CELL IMMUNOTHERAPY

Pub. No.:    WO/2018/183385    International Application No.:    PCT/US2018/024650
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: A61K 35/17
A61K 38/00
A01N 63/00
C07K 14/725
C07K 14/705
C12N 5/0783
Applicants: NATIONAL UNIVERSITY OF SINGAPORE
NKARTA, INC.
Inventors: LEONG, Jun, Hao
SHIMASAKI, Noriko
SEOW, See, Voon
CAMPANA, Dario
TRAGER, James, Barnaby
LAZETIC, Alexandra, Leida Liana
GUO, Chao
BUREN, Luxuan, Guo
MASRANI, Shyam, Sashikant
Title: TRUNCATED NKG2D CHIMERIC RECEPTORS AND USES THEREOF IN NATURAL KILLER CELL IMMUNOTHERAPY
Abstract:
Several embodiments disclosed herein relate to the compositions comprising engineered Natural Killer (NK) cells that express a chimeric receptor, the chimeric receptor imparting to the NK cells an enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several embodiments relate to NK cells that target cells expressing natural ligands of NKG2D, where the NK cells comprise transmembrane and/or signaling domains that lead to cytotoxic and/or cytolytic effects when the NK cells bind a target cell. Uses of NK cell compositions to treat diseases are also provided for in several embodiments.