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1. (WO2018183376) ACVR2A-SPECIFIC ANTIBODY AND METHOD OF USE THEREOF

Pub. No.:    WO/2018/183376    International Application No.:    PCT/US2018/024632
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: C07K 16/28
C07K 16/42
C07K 16/46
Applicants: RIGEL PHARMACEUTICALS, INC.
Inventors: KINSELLA, Todd M.
BHATT, Ramesh
BALTGALVIS, Kristen
Title: ACVR2A-SPECIFIC ANTIBODY AND METHOD OF USE THEREOF
Abstract:
The present disclosure provides antibodies that specifically bind to and block signaling by ACVR2A, i.e., ACVR2A but not ACVR2B, as well as methods for using the same. The antibodies may be used for the treatment of a number of conditions associated with muscle atrophy, as well as other conditions.