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1. (WO2018183369) CRANBERRY-DERIVED COMPOSITIONS FOR POTENTIATING ANTIBIOTIC EFFICACY AGAINST BACTERIAL PERSISTENCE

Pub. No.:    WO/2018/183369    International Application No.:    PCT/US2018/024623
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: A61K 31/702
A61K 31/7034
A61K 31/7048
A61K 31/7036
A61K 31/43
A61K 31/00
A61K 36/45
A61P 31/04
Applicants: RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION
Inventors: ROWLEY, David
SUN, Jiadong
DEERING, Robert
SEERAM, Navindra
COHEN, Paul
Title: CRANBERRY-DERIVED COMPOSITIONS FOR POTENTIATING ANTIBIOTIC EFFICACY AGAINST BACTERIAL PERSISTENCE
Abstract:
The present invention provides compositions derived from cranberry including xyloglucan and pectic oligosaccharides, and iridoid terpene glycosides. These compositions can be used in conjunction with antibiotics to synergistically kill bacterial persister cells and inhibit bacterial quiescent phenotypes, thereby improving treatment outcomes in recurrent and other infections.