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1. (WO2018183353) SMALL MOLECULE COMPOUNDS TO SUPPORT HEALTHY HUMAN AGING
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Pub. No.: WO/2018/183353 International Application No.: PCT/US2018/024601
Publication Date: 04.10.2018 International Filing Date: 27.03.2018
IPC:
A61K 31/192 (2006.01) ,A61K 31/225 (2006.01) ,A61K 31/341 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
225
Polycarboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341
not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
Applicants: CARDAX PHARMA, INC.[US/US]; 2800 Woodlawn Drive, Suite 129 Honolulu, Hawaii 96822, US
UNIVERSITY OF HAWAII[US/US]; 2425 CAMPUS ROAD Honolulu, HI 96822, US
Inventors: ALLSOP, Richard; US
WATUMULL, David G.; US
WILLCOX, Donald Craig; JP
WILLCOX, Bradly; US
Agent: DELUCA, MARK R.; Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C P.O. Box 398 AUSTIN, Texas 78767-0398, US
Priority Data:
62/477,35327.03.2017US
Title (EN) SMALL MOLECULE COMPOUNDS TO SUPPORT HEALTHY HUMAN AGING
(FR) COMPOSÉS À PETITES MOLÉCULES POUR FAVORISER UN VIEILLISSEMENT HUMAIN SAIN
Abstract:
(EN) Disclosed herein are methods of activating expression of the FOXO3 gene in a subject comprising administering to a subject small molecule compound (such as astaxanthin and/or one or more astaxanthin derivatives), or pharmaceutically acceptable salts thereof, in an amount sufficient to at least partially increase the amount of FoxO3 expressed in the subject.
(FR) L'invention concerne des procédés d'activation de l'expression du gène FOXO3 chez un patient, comprenant l'administration à un sujet d'un composé à petites molécules (tel que l'astaxanthine et/ou un ou plusieurs dérivés de l'astaxanthine), ou ses sels pharmaceutiquement acceptables, dans une quantité suffisante pour augmenter au moins en partie la quantité de foxo3 exprimée chez le patient.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)