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1. (WO2018183349) NIRAPARIB FORMULATIONS

Pub. No.:    WO/2018/183349    International Application No.:    PCT/US2018/024597
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: A61K 31/454
C07D 401/10
Applicants: TESARO, INC.
Inventors: MCGURK, Simon
NARAYAN, Padma
MEDENDORP, Clare
WU, George
RUDDY, Stephen
KEMPINSKI, Heidi
STEWART, Alistair
Title: NIRAPARIB FORMULATIONS
Abstract:
The present invention relates to pharmaceutical capsule compositions comprising the compound niraparib as an active pharmaceutical ingredient, suitable for oral administration as well as to methods for their preparation. Also described herein are capsule formulations containing niraparib formed by the disclosed methods, and therapeutic uses of such capsule formulations for treating various disorders and conditions. The niraparib is distributed with substantial uniformity throughout a pharmaceutically acceptable carrier of the capsule formulations and exhibit good long-term stability and dissolution properties.