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1. (WO2018183284) OXIME CROSS-LINKED BIOCOMPATIBLE POLYMER HYDROGELS AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/183284    International Application No.:    PCT/US2018/024503
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: A61L 24/00
A61L 24/04
A61L 31/04
A61L 31/14
C08G 65/00
C08G 65/48
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: CHRISTMAN, Karen
FUJITA, Masaki
MADANI, Michael
Title: OXIME CROSS-LINKED BIOCOMPATIBLE POLYMER HYDROGELS AND METHODS OF USE THEREOF
Abstract:
Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least three component polymers, a first polymer including an aminooxy group, a second polymer including a reactive oxo group, that are cross-linked by oxime bonds and a third polymer including a catechol group, that causes better retention on the cardiac tissue. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.