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1. (WO2018183264) NOVEL ALPHA-HYDROXY CARBOXYLIC ACID AND DERIVATIVES AND OTHER GRAS- BASED PRODRUGS OF OPIOIDS AND USES THEREOF

Pub. No.:    WO/2018/183264    International Application No.:    PCT/US2018/024476
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: A61K 31/485
A61P 25/36
C07D 489/02
C07D 489/04
C07D 489/08
Applicants: THOTTATHIL, John K.
Inventors: THOTTATHIL, John K.
Title: NOVEL ALPHA-HYDROXY CARBOXYLIC ACID AND DERIVATIVES AND OTHER GRAS- BASED PRODRUGS OF OPIOIDS AND USES THEREOF
Abstract:
The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to opioids in a manner that substantially decreases or deters the potential for opioid abuse, addiction, illicit and illegal use, and overdose. When delivered at the proper dosage, the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.